DuPont™ Kalrez® 6221


For Pharmaceutical and Food Handling Applications

Product Description

DuPont™ Kalrez® 6221 perfluoroelastomer parts are a white product that provide superior chemical resistance and low contamination from extractables in pharmaceutical and food handling applications where FDA compliance is required. DuPont™ Kalrez® 6221 parts are especially suited for Water for Injection (WFI) systems, Steam-in-Place (SIP) cleaning and other critical systems. Kalrez° 6221 parts are thermally stable up to 260°C (500°F), permitting them to be used in Stage II Sterilization processes, where other elastomers lose their sealing ability. Kalrez® 6221 is available as O-rings. For white custom parts, please refer to Kalrez® LS205 parts.

Typical Physical Properties



Maximum Service Temperature °C (°F) 260 (500)
Durometer, Shore A (test ASTM D2240) 70
100% Modulus, MPa (psi) (test ASTM DD1414) 7.24 (1049)
Tensile Strength at Break, MPa (psi) (test ASTM D1414) 15.16 (2199)
Elongation at Break (%) (test ASTM D1414) 150
Compression Set, %70 204 °C (400 °F) (test ASTM D395B) 27

Aggressive Water Resistance

In aggressive pharmaceutical processing environments, seal failure from excess swelling, embrittlement, or decomposition can cause unscheduled downtime or product contamination. Elastomeric materials that come in contact with highly pure and aggressive water (e.g. WFI) must be chosen with care in order to prolong seal life. The perfluoroelastomer compounds used in Kalrez® parts have been shown to have extremely low, to non-detectable extractable levels in aggressive water systems. Because the perfluoroelastomer polymer in Kalrez® parts is fully saturated, it is also well suited for Ozonated Deionized Water service. Kalrez® parts also exhibit very low swell and loss of mechanical properties after repeated steam cycling.

General Chemical Resistance

The overall chemical resistance of EPDMs, silicone elastomers and fluoroelastomers (FKM) is limited by their respective polymer structures. Kalrez® parts, on the other hand, offer the same universal chemical resistance as PTFE, but unlike PTFE, they have elastomeric properties, which help them maintain their sealing capabilities. The following table lists the chemical compatibility of Kalrez® 6221 perfluoroelastomer parts and other elastomers used as sealing materials in the pharmaceutical and food handling industries.

Chemical/Product Kalrez® 6221 EPDM Si FKM
Acetic Acid A A A B
Acetone A A C U
Citric Acid A A A A
Hydrogen Peroxide A B B B
Isopropyl Alcohol A A A A
Methyl Ethyl Ketone A A U U
Mineral Oil A U B A
Nitric Acid A B B A
Sodium Hypochlorite A B B A
Soybean Oil A C A A
Steam (<150°C) A A C C
Steam (>150°C) A C U U
Toluene A U U A
Xylene A U U A
Maximum Service Temperature 260°C (500°F) 135°C (275°F) 200°C (392°F) 200°C (392°F)

A = little or no effect. B = slight swelling and/or loss of physical properties. C = moderate to severe swelling and/or loss of physical properties/limited functionality. U = not suitable or recommended

Warranty for Kalrez products

• Only applies to Dupont products distributed genuine in Vietnam.

• All Kalrez products are warranted if the machine fails due to manufacturer fault.

• For warranty and product maintenance, please contact Achilles, customer service phone number: 098 213 2184 (Ms. Duc).

• Achilles is the genuine supplier of products related to Kalrez DuPont.

• For retail/whole sale pricing, bulk ordering and product information advice please contact 098 213 2184 (Ms. Duc) via or the website

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